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ObjectiveTo investigate the specific anti-SARS-CoV-2 antibody in adults and above after initial vaccination with inactivated COVID-19 vaccine, and determine the influencing factors. MethodsIn this study, residents aged 18 and above who had completed two doses of inactivated COVID-19 vaccine in Deqing County, Huzhou City, Zhejiang Province were included. Information such as gender, age, type of vaccine and vaccination time were collected, and serum specimens were sampled. Anti-SARS-CoV-2 receptor binding domain (RBD) antibody was quantitatively examined by enzyma-linked immunosorbent assay (ELISA) and influencing factors were determined. ResultsThe median concentration of anti-SARS-CoV-2 IgG antibody in the residents vaccinated with an inactivated booster vaccine was higher than that in those vaccinated with only two doses of COVID-19 vaccine or single dose (P<0.05). The median concentration of IgG antibody in males was 9.73 (4.01-23.70) RUmL-1, lower than 17.76 (7.07-49.23) RUmL-1 in females (P<0.05). The median concentration in the residents vaccinated with BBIBP-CorV (Sinopharm) was 6.53 (0.97-13.69) RUmL-1, which was lower than that in those vaccinated with CoronaVac (Sinovac) that was 17.29 (8.54-43.73) RUmL-1 (P<0.05). The median concentration in those with BBIBP-CorV was also lower than 12 (5.45-40.06) RUmL-1 in those with heterologous booster vaccine (P<0.05). The median concentration was 9.73 (3.83-23.63) RUmL-1 in the residents with an interval of more than 6 months from the second dose, which was lower than 14.66 (6.36-35.98) RUmL-1 in those with an interval of 3-6 months (P<0.05). Moreover, immune effect was better in females (X2=16.464, P<0.05), 18-45 years (X2=7.158, P<0.05), and those vaccinated with CornaVac (X2=49.637, P<0.05), while decreased in those with an interval of more than 6 months from the second dose (X2=8.447, P<0.05). ConclusionGender, age, and type of vaccine may affect the effect of immunization. The COVID-19 vaccination shows an acceptable immunogenicity in adults;however, it declines in 6 months after vaccination. It warrants strengthening the booster vaccination to maintain the immune response.
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Since the outbreak of COVID-19, digital nomads, a group of people who work remotely while traveling, have been emerging as a hot research topic in the global academic community. With the rising number of digital nomads in China, several tourist destinations, such as Dali in Yunnan, and Anji in Zhejiang, have evolved into digital nomad destinations, and this trend is expanding. However, the concept of digital nomads remains relatively unexamined by China's academic community, as evidenced by the limited academic research and considerable lag of academic research behind industry practice. First, this paper establishes the conceptual foundations of digital nomads based on content analysis. It offers a detailed definition established through an exploration of the work, travel, and lifestyle perspectives of digital nomads. Six indicators have been identified to distinguish digital nomads from remote workers, business travelers, and working tourists, including location independence, mobility, work focus, work digitization, precarity, and travel frequency. Further, the characteristics (including the pursuit of freedom, uninterrupted travel, working while traveling, professional and informational literacy, and invasion and integration of the destination culture) and supporting systems (co-spaces, digital and technical support, and economic and social support) are discussed. Next, this paper investigated the origin and evolution of digital nomads through an analysis of the evolutionary paths of work style from nomadic worker to digital knowmad, and from knowledge worker to digital knowledge worker to digital knowmad, the evolution of leisure travel style from backpacker to flashpacker to flashpacker nomad and the evolution of lifestyle from nomad to global/neo-nomad to digital nomad. Finally, the current state of digital nomad research is surveyed, highlighting research themes, key theoretical frameworks, gaps in knowledge, and areas for future research. Insights into digital nomads are explored, including (1) the applicability of conceptual definitions of digital nomads at the operational level, (2) the practical validity of theoretical frameworks for digital nomad research, (3) the impact of digital nomads on the evolution of destinations, the urban-rural development, digital economic development, and the mechanisms involved, and (4) the emerging research on digital nomads in China with a focus on understanding the unique economic, social and cultural characteristics of digital nomads in China compared to other countries. Based on the insights shared in this paper, future research directions for digital nomads are envisaged. This paper establishes a baseline for the research on digital nomads to guide future scholarly attention toward digital nomad research and provide a basis for the development and practical application of relevant theories in the context of the digital economy.
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The observations of atmospheric CO2 mole fraction in urban area in China are relative sparse. Here, we present the first-hand observation of atmospheric CO2 mole fraction from 2016 to 2020 at a city station (Hangzhou, abbreviated as HZ) in the Yangtze River Delta, which is one of the strongest CO2 source regions in China. The CO2 mole fraction at an adjacent World Meteorological Organization / Global Atmospheric Watch (WMO/GAW) programme site (Lin'an, LAN) are also presented and compared. The temporal variations, seasonal variations, and influence of COVID-19 pandemic are analyzed. Our results show that, the variations of CO2 mole fraction in Hangzhou are mainly driven by the local emissions, both atmospheric dilution conditions (i.e., wind speed, visibility) and topography, and the temporal variations are apparently different with the suburb site of LAN, although the distance between the two stations is only 50 km. During the observation period, the CO2 mole fraction at HZ is on average 15.6 +or- 0.2 ppm higher than LAN, with two distinct peaks observed at 9:00 and 17:00-18:00, corresponding to traffic rushing hours. The growth rate of atmospheric CO2 mole fraction is 11.2 +or- 0.1 ppm yr-1 before the COVID-19 pandemic (from 2016 to 2019), which is much higher than the suburb site of LAN, 5.4 +or- 0.1 ppm yr-1. The COVID-19 pandemic has led to a plunge of atmospheric CO2 mole fraction at HZ in 2020, with a value of 15.7 +or- 0.7 ppm, corresponding to 3.5% lower than the year of 2019. But at LAN, the annual average CO2 mole fraction in 2020 is 1.5 +or- 0.5 ppm higher than the previous year, similar to the trend in the northern hemisphere. The different annual CO2 mole fraction growth rate at HZ indicates that the CO2 mole fraction at Hangzhou may be dominated by local anthropogenic emissions, despite the transport of airmass from the north and southwest.
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This is a title only record which contains no abstract.
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The transmission routes of SARS-CoV-2 include droplet, air and contact transmission, but regardless of the transmission route, the virus must eventually be exposed through the oral, nasal and ocular mucous membranes to invade the human body. Guaranteeing the respiratory protection of front-line medical staff in the prevention and control of COVID-19 is one of the primary tasks of nosocomial infection management. According to "Technical Guidelines for Prevention and Control of COVID-19 in Healthcare Settings (3rd Edition)", oral/nasal cavity can be disinfected with hydrogen peroxide, iodophor, in the event of occupational respiratory exposure. But, at the moment, In the field of nosocomial management, compared with hand hygiene, "mucosal hygiene" is rarely mentioned, especially the treatment of respiratory mucosa after exposure to acute infectious respiratory pathogens, which is still blank in the domestic research. After a rapid literature review, it is found that some antiseptics have been widely used in clinical practices, such as gargling with bactericidal solution before the diagnosis and treatment procedure for dental patients under COVID-19 epidemic, nasal decolonization for patients undergoing elective surgery to prevent surgical site infection, and use of eye drops of antiseptics to prevent neonatal conjunctivitis. In view of the current lack of effective antiviral drugs for treatment of SARS-CoV-2, and the constantly emerging mutant strains can break through the immune barrier of human body, this paper recommends that medical personnel use antiseptics for emergency mucosal disinfection as an supporting measure for respiratory tract protection after accidental exposure to SARS-CoV-2 of oral, nasal and ocular mucosa.
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Objective: To determine the epidemic characteristics of forty-two coronavirus disease 2019 (COVID-19) cluster outbreaks in Hangzhou city and provide scientific evidence for further prevention and control measures.
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Objective: To investigate the epidemiological characteristics of an outbreak of respiratory tract infection caused by human rhinovirus (HRV) in a school in Nanxun District of Huzhou City, and provide scientific evidence for prevention and control of outbreaks of upper respiratory tract infection caused by HRV in the future.
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OBJECTIVE: To understand the status of pollution of cell phones of health care workers from neonatal intensive care unit(NICU) and explore the effect of frequency of regular disinfection on hygiene of cell phones so as to reduce the pollution of cell phones. METHODS: A questionnaire survey was conducted for the status of use of cell phones among the health care workers, the samples were collected from the cell phones of three groups of health care workers that were disinfected with different frequencies by using sterile sponge sticks. Chi square test was carried out to analyze the impact of use habit of cell phones on the hygiene and the impact of different frequencies of disinfection on the hygiene of cell phones. RESULTS: A total of 46 health care workers were enrolled in the study, all of them used touch-screen cell phones, 97.83% of the health care workers used the cell phone when working, 17.39% used sometimes;13.04% of the health care workers never carried out hand hygiene after they used cell phones, only 1(2.17%) health care worker carried out hand hygiene every time after use;the frequency of regular cleaning of cell phones was less than once per day among 69.57% of the health care workers. The majority of the health care workers used disposable disinfectant wipes for the cleaning of cell phones;15.22% of the health care workers used disposable protective covers. The cell phones of 32 health care workers were sampled, the qualified rate of the samples was 34.38%, and pathogens were not isolated. The cell phones maintained clean by using the disposable protective covers. There was no significant difference in the qualified rate of hygiene among the cell phones with different frequencies of disinfection. CONCLUSION: The regular cleaning and disinfection of the cell phones may effectively reduce the bacterial colonization on the surfaces of cell phones, and the use of disposable protective covers may keep the cell phones relatively clean.
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Objective: To analyze the epidemiological characteristics of a family and workplace clustering of COVID-19, identify the source of infection and the transmission chain, and provide evidence for prevention and control of COVID-19 pandemic. Method: Field epidemiological method was used to conduct the investigation of confirmed cases and close contacts in this cluster. Data were analyzed with descriptive method. Real-time fluorescent quantitative PCR (RT-PCR) was used to detect the novel coronavirus nucleic acid in the collected respiratory tract samples.
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Objective: To explore the temporal and spatial distribution characteristics of confirmed cases of coronavirus disease(COVID-19)in Zhejiang Province and to determine the correlation between number of confirmed cases and geographical demographic factors, so as to provide theoretical basis for the prevention and control of COVID-19.
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Objective: To explore the spatiotemporal distribution of COVID-19 in Wenzhou and to provide theoretical basis for the formulation of preventive and control measures.
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This study aims to develop a multi-dimensional night-time economy vitality index (NTEVI) to measure the vitality of night-time economic (NTE) activities in Zhejiang Province, China, covering its 11 cities and 90 counties. Comprising 44 supply and demand indicators of the NTE, the index was composed of an overall index and six major sub-indices that measured the vitality of six typical NTE subsectors, including catering, shopping, recreation, accommodation, touring, and fitness. The NTEVI was calculated using a unique multi-source dataset based on hourly online transaction data from a leading Chinese online-to-offline service platform, monthly night-time electricity consumption data, and official statistics from 2019 to 2020. Robustness and sensitivity analyses were conducted to ensure high credibility of the index results. The findings of this study suggested that the NTEVI was highly and significantly correlated with night light indices, economic indicators, and tourism demand measures. By identifying regional and temporal differences across several service sectors over time at the county, city, and provincial levels, the NTEVI serves as a powerful numerical and visual tool: it offers key information to guide policy formulation, resource allocation, and policy evaluation. In the context of COVID-19, the index analyses also reflect the NTE recovery process in Zhejiang Province. Our findings indicate that it is important for the Chinese government, regional authorities, and enterprises to encourage the NTE as a main driver of economic revitalization.
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Objective: To understand anxiety status among students with hearing loss under the epidemic of novel coronarirus pneumonia, and to provide evidence for promoting mental health of hearing impaired students.
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Objective: To understand the epidemiological characteristics of an outbreak of respiratory tract infection caused by human metapneumovirus (hMPV) in a primary school in Huzhou City, and to provide scientific reference for the prevention and control of the outbreak of upper respiratory tract infection caused by hMPV in the future.
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Objective: To determine the infectivity rate following close contact with confirmed COVID-19 cases in Quzhou from January to September 2020, and to provide reference for pandemic control and prevention.
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The global outbreak of novel Coronavirus Disease (COVID-19) epidemic has seriously endangered people's health and hindered rapid economic development. Geographic analysis of spatial and temporal transmission patterns in key regions can help prevent and control the epidemic. This paper takes Zhejiang province as the research area. With the help of POI data, the methods such as textual analysis, mathematical statistics, and spatial regression analysis are used to analyze the socio-demographic characteristics of confirmed cases and the spatio-temporal evolution of the epidemic, and then analyze its influencing factors. The results show that: (1) The age distribution of confirmed cases spanned a wide range, showing normal distribution of "large in the middle and small at both ends." (2) The epidemic period is divided into five stages: the initial period, the outbreak period, the steady decline period, the internal stable period, and the oversea input period. The interval between the onset time and announcing a confirmed case was mostly 0-6 d, and the time interval of non-local cases is longer than that of local cases, and the onset of most of the non-local cases occur on the day the patients leave their original place. There was no significant gender difference in the proportion of daily incidence, and the proportion of age had stage features. (3) The spatial distribution aligned in the direction of "Southeast-Northwest", the evolution trend developed from "single place distribution" to "multi-area cluster cases" and then to "key input" evolution, with "high-high" "high-low" clustering characteristics;The migration path of confirmed cases presented an obvious core-edge structure, and the first significant flow was from the center of Wuhan. (4) By analyzing the factors affecting the distribution of the epidemic,it is found that the ratio of the elderly population, per capita GDP, the proportion of the tertiary industry, the number of industries above the scale, and the distance from Wuhan were the dominant factors. Finally, several suggestions on targeted prevention and control measures are made, and the weaknesses of the study and future directions of efforts are pointed out.